MEXICOWANDERER
las peñas, michoacan, mexico
Senior Member
Joined: 06/01/2007
View Profile
 Offline
|
Your opinion regarding the apparent viral loading of children ?
50 to 100 times the amount of pathogens ?
Thank you
|
MEXICOWANDERER
las peñas, michoacan, mexico
Senior Member
Joined: 06/01/2007
View Profile
Offline
|
A vital component which is in addition to the above is the amount of fresh new and moving air. Apparently enclosed refrigerated but rather air is much more subject to a high virus count. Even in this cruel heat in the nineties with 60% + R/H. I refuse to set foot in a structure that has enclosed air conditioning even though there may not be a lot of people inside.
|
MEXICOWANDERER
las peñas, michoacan, mexico
Senior Member
Joined: 06/01/2007
View Profile
Offline
|
Looks like the Oxford Covid19 AstraZeneca vaccine is going to pass phase 3 trials as a wild success. Furthermore, the first medically documented reinfection with Covid19 brought zero symptoms.
I suspected from the first that T cells and the TIME that T cell intervention took place is the key and not the manipulation of antigens.
We shall see if my suspicions are correct. The reason that I am excited is all this research lays the basis for vastly improved influenza and even common cold interventions. Basis, not cure.
|
BCSnob
Middletown, MD
Senior Member
Joined: 02/23/2002
View Profile
|
MEXICOWANDERER wrote:Your opinion regarding the apparent viral loading of children ?
50 to 100 times the amount of pathogens ?
Thank you Be aware that viral load, as measured, in many studies does not necessary correlate with infectiousness. The viral load is measured using the amount of RNA detected; the amount of live virus would require a culturing test method. Infectiousness would require being able to pass the live virus onto a health person and make them sick.
This is a very recent review article and a good starting point for a deeper review of the available data. I've quoted a relevant section but there is more information in this article on other aspects.
SARS-CoV-2 detection, viral load and infectivity over the course of an infection
Journal of Infection
Volume 81, Issue 3, September 2020, Pages 357-371
Quote:Duration of SARS-CoV-2 infectivity
Virus culture studies
No study was found that definitively measured the duration of infectivity. Four studies were found that correlated serial rRT-PCR test results with virus cultures.13,45,58,98
No studies measuring how long a COVID-19 positive (rRT-PCR) patient can make another person sick.
Quote:Differences between adults and children
Thirty-six studies included children (18 years or younger) either exclusively,14,26,39,42,47,51,71,84,85,102,106,119 or in combination with adults.12,17,23,30,36,37,40,41,46,48,56,60,62,68,77,78,80,92,93,105,109,111,113,115 No discernible differences with regards to viral load or duration of virus detection were apparent between adults and children. Two included studies compared findings between children and adults, either directly41 or indirectly (through reference to published findings).51
No difference with age on how much viral RNA could be measured.
This is, in my opinion, what makes COVID-19 unique and more dangerous than influenza, MERS, and SARS-CoV-1.
Quote:Viral load in asymptomatic or pre-symptomatic patients
Seven studies measured viral load in pre-symptomatic or asymptomatic patients, and generally found little to no difference in viral load between pre-symptomatic, asymptomatic and symptomatic patients.13,25,30,42,46,48,90
Virus culture studies
Arons et al. conducted virus culture in 46 of the 48 residents of a nursing facility in the US who tested positive for SARS-CoV-2.13 Positive culture growth was recorded in 31 (67.4%) of these upper respiratory tract samples. Viable virus was isolated from asymptomatic, pre-symptomatic and symptomatic residents. The lowest viral load (Ct value) for which there was positive culture growth was 34.3. Viable virus was isolated from specimens collected between six days before, to nine days after, the first evidence of typical symptoms. When atypical symptoms are also considered, viable virus was isolated from samples collected six days before to 13 days after first evidence of any symptoms. One doesn't need to feel sick or look sick to have just as much live virus as those who feel sick.
* This post was
edited 08/24/20 01:38pm by BCSnob *
|
MEXICOWANDERER
las peñas, michoacan, mexico
Senior Member
Joined: 06/01/2007
View Profile
Offline
|
BCSnob,
I am decidedly in favor of using a multi-prong approach to immunization.
The RNA killed virus, weighted vaccine like the Oxford Astra Zeneca
An antigen focused immunization like the Moderna.
I can only wonder if a similar approach is being studied...
|
|
|
BCSnob
Middletown, MD
Senior Member
Joined: 02/23/2002
View Profile
|
We have heard about how underlying health conditions increase the risk for severe Covid-19 infections. Here is an analysis of the percentage and age distribution of these underlying health conditions in the UK which demonstrates how widespread (in age) the increased risks are.
UK prevalence of underlying conditions which increase the risk of severe COVID-19 disease: a point prevalence study using electronic health records
doi: https://doi.org/10.1101/2020.08.24.20179192
Quote:Background This study aimed to describe the population at risk of severe COVID-19 due to underlying health conditions across the United Kingdom in 2019. Methods We used anonymised electronic health records from the Clinical Practice Research Datalink GOLD to describe the point prevalence on 5 March 2019 of the at-risk population following national guidance. Prevalence for any risk condition and for each individual condition is given overall and stratified by age and region. We repeated the analysis on 5 March 2014 for full regional representation and to describe prevalence of underlying health conditions in pregnancy. We additionally described the population of cancer survivors, and assessed the value of linked secondary care records for ascertaining COVID-19 at-risk status. Findings On 5 March 2019, 24.4% of the UK population were at risk due to a record of at least one underlying health condition, including 8.3% of school-aged children, 19.6% of working-aged adults (19–65 years), and 66.2% of individuals aged 70 years or more. 7.1% of the population had multimorbidity. The size of the at-risk population was stable over time comparing 2014 to 2019, despite increases in chronic liver disease and diabetes and decreases in chronic kidney disease and current asthma. Separately, 1.6% of the population had a new diagnosis of cancer in the past five years. Interpretation The population at risk of severe COVID-19 (aged >70 years, or with an underlying health condition) comprises 18.5 million individuals in the UK, including a considerable proportion of school-aged and working-aged individuals.
Quote:We defined the COVID-19 at-risk population as individuals with at least one underlying health condition conferring moderate or high risk of severe COVID-19 according to national guidance. Namely: any history of chronic respiratory disease (excluding asthma), heart disease, kidney disease, neurological conditions such as multiple sclerosis, diabetes mellitus; or current asthma, severe obesity, or immunosuppression......
While the elderly (>70) are at greater risk than other age groups; these data indicate that close to 20% of the working age population (19–65 years) are at greater risk for a severe Covid-19 infection and 8% of school kids are at greater risk. This is an analysis for the UK population; I wonder if the US population is more or less healthy (rates of the underlying health conditions)?
* This post was
edited 08/26/20 07:56am by BCSnob *
|
MEXICOWANDERER
las peñas, michoacan, mexico
Senior Member
Joined: 06/01/2007
View Profile
Offline
|
The horribly obese and diabetic prone adults and children of México are paying an awful price. Neighborhood gossip indicates one-way trips to the hospital or cemetery,that raise the hackles. Children are dying of lung damage and adults are in addition suffering renal failure and cardiac infarction. The government is attributing death to specific failures and not the virus.
What a calamity.
This is the result of too little too late as far as talented advice is concerned. In the south the indigenous shout Covid is a government plot. Village fiestas are anything but sane distancing with cubrebocas (masks). This is superb proof that what medical authorities warn about is not guesswork.
|
RambleOnNW
Pacific Northwest
Senior Member
Joined: 08/06/2010
View Profile
Good Sam RV Club Member
|
Even when a vaccine is available we all may not be home free. For example the Moderna and Pfizer vaccine candidates reportedly require low temperature storage and transportation, -4F for Moderna and -94F for Pfizer:
https://www.marketwatch.com/story/modern........ge-distribution-2020-08-27?mod=home-page
2006 Jayco 28', E450 6.8L V10, Bilstein HDs,
Roadmaster Anti-Sway Bars, Blue Ox TigerTrak
|
BCSnob
Middletown, MD
Senior Member
Joined: 02/23/2002
View Profile
|
That problem has been solved for decades. Companies (including mine) regularly ship perishable pharmaceuticals on cold packs or dry ice nationwide and internationally.
|
RambleOnNW
Pacific Northwest
Senior Member
Joined: 08/06/2010
View Profile
Good Sam RV Club Member
|
BCSnob wrote:That problem has been solved for decades. Companies (including mine) regularly ship perishable pharmaceuticals on cold packs or dry ice nationwide and internationally.
-94F is -70C. This company says they can ship 240 hour pallets with -78C.
What capability does your company provide?
https://www.dryce-pharma.com/
|
|
|
|
