d1h
Indiana
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vic789 wrote:We hope this pandemic will end soon
It will most likely eventually become like the flu. It will always be with us and if you want protection from it you will probably need a yearly shot just as you would for the flu.
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silversand
Montreal
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....I think that Danny Altman, Professor Department of Immunology and Inflammation, Imperial College, London expressed the situation well in poetic words:
Quote:"Professor Danny Altmann, from Imperial’s department of immunology and inflammation, said: "The message is a little bleak. Omicron and its variants are great at breakthrough, but bad at inducing immunity, thus we get reinfections ad nauseam, and a badly depleted workforce."
"Not only can it break through vaccine defenses, it looks to leave very few of the hallmarks we’d expect on the immune system – it’s more stealthy than previous variants and flies under the radar, so the immune system is unable to remember it."
https://www.imperial.ac.uk/news/237315/omicron-infection-poor-booster-covid-19-immunity/amp/ link here-->
Silver
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silversand
Montreal
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....anecdotally, in our region of extreme southeastern Quebec near the Vermont frontier, 40% of the people we know closely have gotten infected (and confirmed) with Covid over the past 12 days.
This would infer that some high level of spread is now underway. Recently. And, our CLOSEST friends are giving us daily updates: fully vaccinated all with mRNA, in excellent shape and athletic, no known preconditions, and the infections are BRUTAL and debilitating from whatever this variant is.
We are back to N95 now 100% masking in indoor public places. Just when we thought we were free and clear. Quebec has been mask free for appx 2 weeks now ![[emoticon]](http://www.coastresorts.com/sharedcontent/cfb/images/mad.gif "mad")
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way2roll
Wilmington NC
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silversand wrote:....I think that Danny Altman, Professor Department of Immunology and Inflammation, Imperial College, London expressed the situation well in poetic words:
Quote:"Professor Danny Altmann, from Imperial’s department of immunology and inflammation, said: "The message is a little bleak. Omicron and its variants are great at breakthrough, but bad at inducing immunity, thus we get reinfections ad nauseam, and a badly depleted workforce."
"Not only can it break through vaccine defenses, it looks to leave very few of the hallmarks we’d expect on the immune system – it’s more stealthy than previous variants and flies under the radar, so the immune system is unable to remember it."
https://www.imperial.ac.uk/news/237315/omicron-infection-poor-booster-covid-19-immunity/amp/ link here-->
But people and their immune systems evolve as well. There are hosts of things that would probably kill us were it not for thousands of years of evolution.
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pianotuna
Regina, SK, Canada
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Any credence to using a Betadine nasal spray as a prophylactic for covid?
https://pubmed.ncbi.nlm.nih.gov/34026595/
Regards, Don
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BCSnob
Middletown, MD
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This small study found 0.5% povidone-iodine nasal spray was effective at reducing the culturable virus in PCR positive patients
Aust J Otolaryngol 2022;5:2.
This study found the nasal spray was effective (your posted study)
Indian J Otolaryngol Head Neck Surg (2021)
This small study found the nasal spray was no more effective than saline spray.
The Laryngoscope 2022
Not many clinical trials and these have been small. It's hard to know how effective the spray is at inactivating the virus in PCR positive patients with the goal to prevent transmission. I would be less confident at the spray preventing inhaled viral aerosols from infecting the respiratory tract when inhaled through the nose (mouth breathers are unprotected).
A clinical trial to test the effectiveness of the nasal spray at preventing infection would need to be similar in size (10,000s of subjects) and just as difficult as a trial to measure the effectiveness of a new vaccine where a large portion of the population already has some immunity (either natural and/or vaccine induced). You'd need enough subjects in the placebo arm to measure the level of community transmission (exposure to virus which also leads to infection) and an equal number receiving the povidone-iodine spray to measure the reduced level of infections. The two arms would also need an equivalent mix of immunity.
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BCSnob
Middletown, MD
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It's interesting, to me, some viral infections produce life long duration of immunity (chickenpox, measles, smallpox, etc) while other viral infections yield shorter durations of immunity (influenza, norovirus, respiratory syncytial virus, human rhinovirus, human common cold coronavirus, etc). What is it about viruses that elicit such different duration of immunities?
Perhaps a combination of viral evolution (or lack thereof) and varying levels of induced immune responses (for example mild/asymptomatic COVID-19 infections induce weak immune responses).
Is it really surprising that vaccines (portions of these viruses used to elicit immune responses without causing infection) would have drastically different (longer) durations of immunities than the viral infection?
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silversand
Montreal
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BC Snob wrote:Perhaps a combination of viral evolution (or lack thereof) and varying levels of induced immune responses (for example mild/asymptomatic COVID-19 infections induce weak immune responses).
...what if "humans" don't mount a strong immune response, like a viral incursion in the upper respiratory tract only by Omicron or, a cold virus (ie. the body sees the virus as a low threat = very mild Covid or mild cold = undetectable post-infection antibodies (weak immune response) ) ? So, humans just continue to get moderately / mildly re-infected over and over again by ever-mutating cold and cov-2 viruses (among others)....
(Slifka; Oregon National Primate Research Center)
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way2roll
Wilmington NC
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silversand wrote:BC Snob wrote:Perhaps a combination of viral evolution (or lack thereof) and varying levels of induced immune responses (for example mild/asymptomatic COVID-19 infections induce weak immune responses).
...what if "humans" don't mount a strong immune response, like a viral incursion in the upper respiratory tract only by Omicron or, a cold virus (ie. the body sees the virus as a low threat = very mild Covid or mild cold = undetectable post-infection antibodies (weak immune response) ) ? So, humans just continue to get moderately / mildly re-infected over and over again by ever-mutating cold and cov-2 viruses (among others)....
(Slifka; Oregon National Primate Research Center)
Everything mutates and evolves all the time. From plants to fish to bugs, to viruses to people. It's survival of the fittest.
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MEXICOWANDERER
las peñas, michoacan, mexico
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https://www.medicalnewstoday.com/article........6084351fd4c466034232ee06e493377eac340d6a
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