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Abstract
The origin of the SARS-CoV-2 is still unclear. Simply said, its emergence is due to the acquisition of the polybasic furin cleavage site on the S protein in one of its closest relatives. The recent discovery in Laos of bat Rhinolophus coronaviruses that contain receptor binding domains almost identical to that of SARS-CoV-2, and despite not having the furin site, they can therefore infect human cells (1), is the cornerstone to identify the SARS-CoV-2 progenitor. However, it is not yet known where the insertion of the furin site at the S1/S2 junction in the S protein of the pandemic virus came from. Not only from where, but also how and when of such acquisition. The most surprising was: (i) that the polybasic furin cleavage site is unique to SARS-CoV-2 among Sarbecovirus (2), and (ii) that the inserted four amino acid motif has a CGG-CGG encoded arginine pair which is rare in coronaviruses (3). So, my question is if the SARS-CoV-2 insert in the S gene insert would match to human transcripts. Here, I address this issue by using NCBI and GISAID databases, the NCBI Human Genome Resources, sequence analysis tools and in-house developed bioinformatic tools. I found that the 12-nucleotide insert encoding SARS-CoV-2 furin site 100% match to several human transcripts. Taken together the presence of these human transcripts and the expression patterns their genes, results provide insight into human potential recombination link to SARS-CoV-2 furin cleavage site, during undetected human-to-human virus transmission. Other PRRA-like insertions in the SARS-CoV-2 spike protein are shown.

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VAERS is a national vaccine safety surveillance program that was established in 1990 and is co-managed by the Centers for Disease Control and Prevention (CDC) and FDA (10). VAERS serves as a hypothesis-generating, early warning system that scientists at FDA and CDC use to detect unusual or unexpected patterns of adverse events (also known as “safety signals”) that warrant further investigation (11, 12). As a passive reporting system, VAERS relies on individuals reporting adverse events after vaccination. Anyone can submit reports to VAERS, including patients, family members, healthcare providers, and vaccine manufacturers (13). No proof that the event was caused by the vaccine is required for VAERS to accept the report (14). Serious and unexpected medical events (such as death) are probably more likely to be reported than minor events, even if they may be coincidental and related to other causes (14). Reports of adverse events, including death, do not necessarily mean that the reported problem was caused by a vaccine. This is especially true for VAERS reports for COVID-19 vaccines, since healthcare providers who administer COVID-19 vaccines are legally required to report to VAERS any deaths following vaccination, regardless of causality (15). (For mandatory reporting requirements, see each COVID-19 vaccine “Fact Sheet for Healthcare Providers Administering Vaccine”) (16-18). For these reasons, interpreting VAERS data without an understanding of its purpose, strengths, and limitations can lead to erroneous conclusions about cause and effect (19).

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our analysis of VAERS data for COVID-19 vaccines found that reporting rates for death events were much lower than expected all-cause mortality rates, and trends in reporting rates reflected known trends in background mortality rates

way2roll wrote:

I found this article interesting. Apparently in WI data suggests that 42% of recent deaths from Omicron variant were people who were vaccinated.

link

d1h wrote:

The grim milestone of this endless pandemic was just hit a few days ago. Over 1 million people have perished in the US because of it. Hopefully they will get the perfect vaccine developed that will crush this disease and will only be a once a year jab like the flu shot.

Moderator wrote:

There is no 'perfect' vaccine available anywhere. The problem with the death rate in the US, IMO, is the large number of people refusing to get vaccinated.

Moderator wrote:

There is no 'perfect' vaccine available anywhere. The problem with the death rate in the US, IMO, is the large number of people refusing to get vaccinated.