BCSnob wrote:

No thanks, I’ll spend my time reading peer reviewed research articles instead of opinion websites. At least with research articles the authors provide the raw data, they tell you how they collected and how they analyzed it that way everyone can review and assess their conclusions. The authors also tell you the limitations of their study.

PDQXYZ wrote:

Take a crack at telling us the factual errors pretty please???

Quote:

Abstract.
Global population immunity to SARS-CoV-2 is accumulating through heterogenous combinations of infection and vaccination. Vaccine distribution in low- and middle-income countries has been variable and reliant on diverse vaccine platforms. We studied B-cell immunity in Mexico, a middle-income country where five different vaccines have been deployed to populations with high SARS-CoV-2 incidence. Levels of antibodies that bound a stabilized prefusion spike trimer, neutralizing antibody titers and memory B-cell expansion correlated with each other across vaccine platforms. Nevertheless, the vaccines elicited variable levels of B-cell immunity, and the majority of recipients had undetectable neutralizing activity against the recently emergent omicron variant. SARS-CoV-2 infection, experienced prior to or after vaccination potentiated B-cell immune responses and enabled the generation of neutralizing activity against omicron and SARS-CoV for all vaccines in nearly all individuals. These findings suggest that broad population immunity to SARS-CoV-2 will eventually be achieved, but by heterogenous paths

Quote:

In this study, we examined the acquired immunity through three vaccines (mRNA-1273, BNT162b2, JNJ-78436735) that have been administered in the United States by characterizing breakthrough cases in a large, vaccinated population across California, Oregon, Washington, Alaska, and Montana. We also conducted pairwise-comparison of the acquired immunity of the vaccines, matching individual vaccine cohorts based on sex, ethnicity, age, and timing of the completion of the recommended initial dose(s). As of November 5th, 2021, 2,627,914 patients (mRNA-1273: 1,087,796; BNT162b2: 1,350,422; JNJ-78436735: 189,696) were fully vaccinated and 0.36% (N=9,321) tested positive after vaccination. All three vaccines showed a high probability of survival against breakthrough cases (mRNA-1273: 0.997, BNT162b2: 0.997, JNJ-78436735: 0.992 in 180 days). In terms of individual performance, two doses of mRNA-1273 was the most effective and a single dose of JNJ-78436735 was least effective among the three administered immunizations (168, 155, and 130 median days to breakthrough, P<0.05). These results remained robust in propensity score analyses. The present results support evidence of previous studies (9–11).

Quote:

Additionally, we examined the acquired immunity through prior COVID-19 infection (64,424 patients) for preventing reinfection. We found a median survival time of 162 days and a mean of 191 days, with an asymptotic probability for avoiding reinfection of 0.995 at 180 days, which is comparable to vaccine-induced immunity breakthrough. We must be careful in comparing these numbers since we have a larger threshold between reinfected cases and breakthroughs. There is also a substantially greater risk of mortality subsequent to SARS-CoV-2 infection than there is to vaccination. We adjust for this by multiplying the resulting survival probability for reinfection by the probability of surviving after 90 days. This gives an adjusted survival of reinfection probability of 0.945 at 180 days.