BCSnob
Middletown, MD
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Joined: 02/23/2002
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Yes, we’ve been getting the news about increasing rates from various sources.
We have a good friend that had surgery at a major hospital in Baltimore. She went from ICU to an external rehab facility because the hospital had no rooms available once she no longer needed ICU care. She stayed in an ICU bed until she was able to be discharged.
The safety officer at work told me about the weekly new reports of employees that are under quarantine because of Covid exposures outside of work. For a few days I thought I might be one but our exposure to someone feeling sick; her tests (rapid and PCR) came back negative (the only negative test for the testing location used).
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BCSnob
Middletown, MD
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Joined: 02/23/2002
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This study from the us military included an evaluation of wild type, alpha, beta, and delta induced natural immunity (previous infection) for the neutralization of wild type, delta, and omicron pseudo viruses. These serum samples were collected 30 days after onset of symptoms (before waning of antibodies). All had reduced neutralization against omicron relative to wild type and delta. This study also includes serum from 2 & 3 doses of Pfizer with the expected performance; boosting required to restore neutralization against omicron.
SARS-CoV-2 Omicron neutralization by therapeutic antibodies, convalescent sera, and post-mRNA vaccine booster
BioRxiv Preprint 22 Dec 2021
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Deb and Ed M
SW MI & Space Coast, FL USA
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Joined: 06/07/2004
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There are SOOOOO many people walking around thinking they are still protected because they are recovered from a previous case of Covid :-( Omicron is really going to enjoy holiday gatherings....
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BCSnob
Middletown, MD
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Novavax has been developing a recombinant protein plus adjuvant vaccine for SARS-CoV-2 which can be shipped refrigerated (not frozen). The WHO recently (20 Dec 2021) gave interim approval for its use.
Here is a phase 2 study (small study ~100) of Novavax’s performance against wild type, alpha, beta, delta, and omicron after the initial 2 dose course (14 days) and post booster (28days). The performance was assessed by measuring the ability of the serum to inhibit the binding of ace2 to the pseudo viruses. There was similar reduced inhibition against alpha, beta, and delta and an additional reduction against omicron following the initial 2 doses of vaccine. Boosting increased the inhibition against all variants tested relative to that after the initial 2 doses and there was a smaller difference between the variants.
Immunogenicity and Safety Following a Homologous Booster Dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): A Phase 2 Randomized Placebo-Controlled Tria
MedRxiv preprint 23 Dec 2021
Now hopefully the FDA will approve the use of this vaccine which only requires refrigeration.
* This post was
edited 12/25/21 08:44am by BCSnob *
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dturm
Lake County, IN
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The production and distribution of Novavax will tremendously aid worldwide efforts in combatting this pandemic. Many places in the world where refrigeration is not available can utilize this vaccine just using an igloo cooler.
Doug & Sandy
Kaylee (16-year-old Terrier of some sort)
Winnie 4 1/2 year old golden
Sasha and many others at the Rainbow Bridge
2008 Southwind
2009 Honda CRV
Check out blog.rv.net
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Deb and Ed M
SW MI & Space Coast, FL USA
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So finally, the numbers for the State of Florida are finally closer to the stuff the county health department is reporting - which implies that Omicron is creating the highest peak in new-case numbers yet recorded (Brevard supposedly is at 199 new cases per day per 100k population - that's incredibly-high). And yet the New Year's celebrations go on, and all the football games, cruise ships are sailing, etc.
The news (NBC I think?) said yesterday that the quick-result PCR tests are not picking up on Omicron? My guess is that by the time someone goes for testing, the virus is already waning? So it's hardly a surprise by how fast this variant is spreading....
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BCSnob
Middletown, MD
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Watch for the numbers on Jan 4 to 6, 2022
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dturm
Lake County, IN
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The PCR tests aren't quick result. The way the tests are run require "amplification" of the genetic material that is on the swab. This takes time.
The antigen tests are the quick result tests and just test for a section of the virus in question. The FDA reported that the antigen tests have reduced sensitivity to the omicron variant - more false negatives.
FDA
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Deb and Ed M
SW MI & Space Coast, FL USA
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dturm wrote:The PCR tests aren't quick result. The way the tests are run require "amplification" of the genetic material that is on the swab. This takes time.
The antigen tests are the quick result tests and just test for a section of the virus in question. The FDA reported that the antigen tests have reduced sensitivity to the omicron variant - more false negatives.
FDA
Thank you for that clarification - that's what I thought originally - so my ears had pricked up when the news people called it a "Fast PCR". Certainly explains these cruise ships coming back to port with a bunch of covid-sufferers.
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nickthehunter
Midwest
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Joined: 07/18/2005
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Deb and Ed M wrote:dturm wrote:The PCR tests aren't quick result. The way the tests are run require "amplification" of the genetic material that is on the swab. This takes time.
The antigen tests are the quick result tests and just test for a section of the virus in question. The FDA reported that the antigen tests have reduced sensitivity to the omicron variant - more false negatives.
FDA
Thank you for that clarification - that's what I thought originally - so my ears had pricked up when the news people called it a "Fast PCR". Certainly explains these cruise ships coming back to port with a bunch of covid-sufferers. My PCR took about an hour, not sure how much faster someone would want.
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