BCSnob
Middletown, MD
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Joined: 02/23/2002
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I have not seen/found a summary that shows the neutralization titers for convalescent serum from one variant against all the other variants.
For example:
Serum from a Wuhan infection tested for neutralization against alpha, beta, delta, omicron, etc
Serum from Delta infection tested for neutralization against Wuhan, alpha, beta, omicron, etc.
I have seen a few studies that evaluated subsets:
Two doses of SARS-CoV-2 vaccination induce more robust immune responses to emerging SARS-CoV-2 variants of concern than does natural infection.
Research Square Preprint
This study even distinguished between convalescent serum from mild and asymptomatic infections.
I know of no database (government website) where reinfections are recorded with the variant that caused the first infection and the variant causing the reinfection. Relative to the number of infections, very few were genetically evaluated (variant identified).
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pianotuna
Regina, SK, Canada
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Joined: 12/18/2004
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I've had two Phizer and one Moderna booster. It is time to boost again. Are there recommendations on which vaccine to get?
Regards, Don
My ride is a 28 foot Class C, 256 watts solar, 556 amp-hours of Telcom jars, 3000 watt Magnum hybrid inverter, Sola Basic Autoformer, Microair Easy Start.
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BCSnob
Middletown, MD
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Joined: 02/23/2002
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I’ve not studied this enough to provide a recommendation. What I have seen suggests the antibody titers decline more rapidly following the 4th and 3rd shots than from the 2nd shot. If immunity is solely based upon antibody titers (which it is not), one might want to time the next booster to the steeply rising community case rates to maximize protection when community exposure risk is the highest. I don’t even know when that might be for my situation let alone someone else’s.
My wife did learn a way to get a free measure of her antibody titer; donate blood to the Red Cross. They are testing donated blood for possible use as “convalescent serum”; the information indicated that the test they’re using cannot distinguish between natural and vaccine induced antibody titers. Her titer was still high enough after 3rd shot for her donated blood to be used as convalescent serum.
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MEXICOWANDERER
las peñas, michoacan, mexico
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Joined: 06/01/2007
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There are disappoint med news comments that state antibody titers decrease rapidly after the third inoculation. If they offer a full strength one it may bump it up.
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jetboater454
Camping or home
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Joined: 07/21/2009
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Now I need to ask my doctor if I can get a blood test for "convalescent serum." I can't donate blood due to "mad cow disease" from being in Germany in early 80's.
2011 Toyota Tundra DC Long Bed
2001 Harley Dyna Lowrider
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steveh27
Grosse Pointe Woods, MI
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Joined: 08/21/2004
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I've had 4 Pfizer shots and 2 shots of evushed, monoclonal antibodies.
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ivbinconned
highway 16
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Joined: 09/27/2003
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18 in our family. All have had the shots except the two youngest and the wife and I, the two oldest. We are in our 70’s.
Two daughters had bad reactions to the shots, one has ongoing suffering and has been to emergency 4 times. Doctors quietly confirm it’s a reaction to the jabs.
All have had Covid except the wife and I!!
Go figure.
Ram and 34 ft Cedar Creek
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BCSnob
Middletown, MD
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Joined: 02/23/2002
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This is the vaccine I’ve been waiting for and I may try to hold out on my 4th shot until it is available.
Safety, Immunogenicity and Antibody Persistence of a Bivalent Beta-Containing Booster Vaccine
Research Square preprint
Quote:Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants have caused multiple waves of infection globally. This phase 2/3 study evaluated the safety and immunogenicity of the bivalent vaccine candidate mRNA-1273.211 (equal mRNA amounts of ancestral SARS-CoV-2 and Beta variant spike proteins) as 50-µg (n=300) and 100-µg (n=595) first booster doses approximately 8.8-9.8 months after the mRNA-1273 primary series. The mRNA-1273.211 booster (50 and 100-µg) elicited higher neutralizing antibody responses against the ancestral SARS-CoV-2 and the Beta variant than that after the second mRNA-1273 dose. Antibody responses after the 50-µg mRNA-1273.211 booster dose were also higher than that after a 50-µg mRNA-1273 booster dose for the ancestral SARS-CoV-2, Beta, Omicron and Delta variants (28 days after the booster dose) and for the ancestral SARS-CoV-2, Beta and Omicron (180 days after the booster dose), and the immunogenicity objectives were met. The safety and reactogenicity profile of the mRNA-1273.211 booster (50-µg) was comparable to mRNA-1273 (50-µg). These results indicate that bivalent booster vaccines can induce potent and durable antibody responses providing a new tool in response to emerging variants.
This is from Moderna’s press release
Quote:Moderna is evaluating an updated bivalent booster incorporating more Omicron-specific mutations (mRNA-1273.214) in a Phase 2/3 clinical study; initial data on this candidate, expected in the second quarter, will inform selection of fall 2022 booster for Northern Hemisphere
This type of vaccination (bi or multivalent) provide greater breadth of protection in terms of viral genetic variability; it’s the same concept as the seasonal flu vaccine.
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Deb and Ed M
SW MI & Space Coast, FL USA
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Joined: 06/07/2004
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That's exciting news! I'm assuming the hope will be for one annual shot? I just got Moderna #4 before we traveled back to Michigan - I'm starting to feel pin-cushiony....LOL! Still beats risking Covid - we celebrated Easter with our niece-in-law's family - her Dad was in the ICU barely hanging onto life a year ago due to Covid. He STILL has no sense of taste or smell; and is always short-of-breath - but very grateful that he's alive!
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ivbinconned
highway 16
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Joined: 09/27/2003
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Now we have another very healthy family member with a possible bad reaction to the vax.
She is 17 with no other health conditions and is Beautifully slim. 4 days ago developed a painful blood clot in her leg!! Lots of swelling from the knee down.
Fortunately it has diminished on its own.
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