Moderator
Tennessee
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Joined: 01/19/2004
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Let's keep the topic on those treatments which have been proven to be effective. Thank you.
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monkey44
Cape Cod, MA and Central Fla
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Joined: 11/12/2002
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Mod -- I think it's important to at least touch on those ineffective treatments as well, even briefly. Otherwise, some folks might believe the 'elixir of life' some pharmaceutical companies pedal to the unwary. Not everyone is educated enough in this field to know the difference.
Remember the 'elixir' of the old west, a mixture of morphine, cocaine and large shot of alcohol made the patient feel great but was no benefit to cure chronic illness. We should advise folks about the treatments that do not function as claimed as well as those that do function as successful treatments.
Monkey44
Cape Cod Ma & Central Fla
Chevy 2500HD 4x4 DC-SB
2008 Lance 845
Back-country camping fanatic
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Moderator
Tennessee
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A 'brief' acknowledgement of those drugs/vaccines shown ineffective is fine. To belabor the topic and/or promote those that are ineffective serves no constructive purpose.
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BCSnob
Middletown, MD
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Joined: 02/23/2002
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One comment on the evaluation of treatments. Since, as many are prone to point out, most people who get infected do recover; effective treatments need to demonstrate lessened severity, decreased duration of symptoms, or decreased deaths. Proof of any of these will require more than, “I got better while taking ______” since most just get better. Also the disease has a range of symptoms and severity, saying “my symptoms were less taking ______” has no meaning unless you know what your symptoms would have been without _____.
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MEXICOWANDERER
las peñas, michoacan, mexico
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The role of a corticosteroid Dexamethasone has shown to be effective in studies approved by the FDA. I find this interesting in that it suggests immune system hyper misfires. But I have yet to uncover if this information includes the Ómicron variant or only the earlier A, B, and Delta viruses. Meaning involvement of the pulmonary system.
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BCSnob
Middletown, MD
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This is the first study I've seen of:
Virological characteristics of SARS-CoV-2 BA.2 variant
BioRxiv preprint 15Feb2022
The authors evaluated the effective replication number from sequencing data across several countries. The authors looked at the effectiveness of antibodies produced by vaccines and past infections to neutralize a pseudovirus of BA.2. An then looked at the types of infections produced in an animal model relative to that produced by BA.1. This summarizes their findings.
Quote:Although BA.2 is considered as an Omicron variant, its genomic sequence is heavily different from BA.1, which suggests that the virological characteristics of BA.2 is different from that of BA.1. Here, we elucidated the virological characteristics of BA.2, such as its higher effective reproduction number, higher fusogenicity, higher pathogenicity when compared to BA.1. Moreover, we demonstrated that BA.2 is resistant to the BA.1-induced humoral immunity. Our data indicate that BA.2 is virologically different from BA.1 and raise a proposal that BA.2 should be given a letter of the Greek alphabet and be distinguished from BA.1, a commonly recognized Omicron variant.
The severity of the disease from BA.2 was studied in an animal model relative to BA.1; the authors did not have this comparison in humans. However, the data does indicate that infection induced immunity from BA.1 will likely not provide immunity against BA.2.
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MEXICOWANDERER
las peñas, michoacan, mexico
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Have studies been performed determining post mRNA vaccination with altered susceptibility of contracting H1N1 or H3N2 influenza?
* This post was
edited 02/17/22 09:01pm by MEXICOWANDERER *
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BCSnob
Middletown, MD
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I’ve not seen any. I wouldn’t expect any protection against influenza with the mRNA vaccines (influenza gains cell entry by another pathway besides ACE2). It might be difficult to identify changes in influenza infection rates (decreased or increased) due to the mRNA vaccines since masking (often correlated with those who choose to be vaccinated) will reduce the rates of other airborne respiratory diseases.
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BCSnob
Middletown, MD
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This quote (a good summary on treatments) is from a recently published clinical trial.
Quote:Despite the success of COVID-19 vaccines and the implementation of nonpharmaceutical public health measures, there is an enormous global need for effective therapeutics for SARS-CoV-2 infection. At present, repurposed anti-inflammatory drugs (dexamethasone, tocilizumab, and sarilumab),1-3 monoclonal antibodies,4-6 and antivirals (remdesivir, molnupiravir, and nirmatrelvir/ritonavir)7-9 have demonstrated treatment benefits at different stages of COVID-19.10
The linked article has the references to the information on these treatments.
Source
Efficacy of Ivermectin Treatment on Disease Progression Among Adults With Mild to Moderate COVID-19 and Comorbidities
JAMA
* This post was
edited 02/18/22 11:08am by BCSnob *
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MEXICOWANDERER
las peñas, michoacan, mexico
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No recorded reinfections of Ómicron when vaccinated? JAMA notes no cases of reinfection with any Ómicron variant .1 or .2 when vaccinated?
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