BCSnob
Middletown, MD
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The time to build immunity is a poor argument because it takes time to build immunity after a covid infection. That is controlled by our immune system not the vaccine (as long as the vaccine elicits an immune response which has been found in all the continuing clinical trials).
This review article found that it took on average (actually median) 11 days post symptoms for antibodies to SARS-CoV-2 to be detected (see figure 2 and associated text).
A systematic review of antibody mediated immunity to coronaviruses: kinetics, correlates of protection, and association with severity
Nature Communications volume 11, Article number: 4704
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BCSnob
Middletown, MD
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I have recently seen a few studies evaluating nasal sprays that bind ACE2 in lungs and nasal passages and thereby block SARS-CoV-2 from binding to the ACE2 receptor which starts the infection process.
This is all very early research.
Intranasal fusion inhibitory lipopeptide........ntact SARS-CoV-2 transmission in ferrets
ACIS, A Novel KepTide™, Binds to ACE-2 R........s: Therapeutic Implications for COVID-19
Intranasal Administration of ACIS KEPTID........rophylactic Role of KEPTIDE™ in COVID-19
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qtla9111
Monterrey, Mexico
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silversand wrote:gtla9111 wrote:Even after the second vaccination, there is a waiting period of a few weeks before immunity can kick in. So for a long period after vaccines are available we will continue to wear masks. That should help to further reduce the number of deaths of those where the vaccine is not fully effective. Right?
Chris....if you can, have a look at PBS News Hour last evening 6:40 PM EST, entitled, "Head of NIH urges Americans to take precautions while awaiting vaccine", Dr Francis Collins, the NIH head, delves into the Emeregency vaccine verification procedure (and, the intense independent review that goes into any vaccine before it is "early released" by the Federal review board). He is imploring Americans to please use masking and social distancing, because though 2 vaccine candidates look promising, no vaccine will be widely-deployed before at least April across through September next year: here-->
Thanks for the link. I usually watch PBS at night but have been busy with the families of friends who are intubated or have died from Covid in the last two weeks.
I posted this because our president is saying that the virus is under control which is misleading the population. Here in Mexico it is actually exploding. Private hospitals were originally asked to take non-Covid cases for surgeries, etc. and today they have changed that to take in Covid patients. If it is under control and there are beds available, I ask myself, why then are they now sending patients to private hospitals?
I have made it clear to family and friends that this will go on well into the end of next year and even then, the tendency will be to social distance and wear masks.
Like social media, fast food, and cell phones, people are looking for instant gratification. The virus isn't going away. We are looking for a way to protect ourselves via the vaccine to survive. A lot of damage has been done by certain groups to the contrary for lack of education and science.
I watched a very good documentary Blaming Wuhan The Documentary. In the Americas, from Canada to Chile, we just don't have that culture for lack of trust in government, discipline and following rules.
I will check out the PBS document. Thanks again.
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BCSnob
Middletown, MD
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SARS-CoV-2-specific T cell memory is lon........ity of convalsecent COVID-19 individuals
Memory T cells (which produce antibodies against SARS-CoV-2) were detected in 84% of patients 9 months after infection. Asymptomatic patients were more likely to have loss of memory T cells than symptomatic patients.
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silversand
Montreal
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Chris:
Thanks for the link to the Wuhan docu. I'll try and watch this tomorrow. It sounds like an extremely dire situation in your region of Mexico, and indeed across the entire republic. Be careful out there!
BCSnob:
I will definitely read through your links today; thanks.
....but the elephant in the room still is: .....how long will immunity last in all cohorts and all complications among those very early P3 vaccine candidates?
Silver
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pianotuna
Regina, SK, Canada
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silversand,
We can only wait and hope.
Perhaps it may be similar to the song 16 tons?
Regards, Don
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BCSnob
Middletown, MD
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silversand wrote:...but the elephant in the room still is: .....how long will immunity last in all cohorts and all complications among those very early P3 vaccine candidates?
This is always the issue with “real time studies”; you have to wait “real time” to get the answers.
We can extrapolate to get some hope.
1. Immunity is correlated with neutralizing antibodies
2. IgG antibodies for the spike (or receptor binding domain) appear to be the neutralizing antibodies
3. Patients in China continue to have IgG antibodies (produced by memory cells) against the spike 9 months post infection
4. The vaccines being tested have been shown to induce the production of IgG antibodies for the spike and/or neutralizing antibodies
5 Memory cells were produced by mRNA SARS-CoV-2 vaccine in animal models (Link)
While searching the literature I found a study that reported people who were infected with SARS-CoV-1 continue to have memory cells against that virus after 11 years post infection.
* This post was
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MEXICOWANDERER
las peñas, michoacan, mexico
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Is there a single empirical database for all the Phase III serology participants?
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qtla9111
Monterrey, Mexico
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silversand wrote:gtla9111 wrote:Even after the second vaccination, there is a waiting period of a few weeks before immunity can kick in. So for a long period after vaccines are available we will continue to wear masks. That should help to further reduce the number of deaths of those where the vaccine is not fully effective. Right?
Chris....if you can, have a look at PBS News Hour last evening 6:40 PM EST, entitled, "Head of NIH urges Americans to take precautions while awaiting vaccine", Dr Francis Collins, the NIH head, delves into the Emeregency vaccine verification procedure (and, the intense independent review that goes into any vaccine before it is "early released" by the Federal review board). He is imploring Americans to please use masking and social distancing, because though 2 vaccine candidates look promising, no vaccine will be widely-deployed before at least April across through September next year: here-->
Thanks for the link. I watched the video and will be sharing it. "The cavalry is on its way ".
Still not sure why people aren't wearing masks. Why would doctors wear them if they were truly useless? We're fanatics about this and rightly so. We haven't been to a restaurant since March and no visitors to the house.
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BCSnob
Middletown, MD
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Quote: Effect of Vitamin D3 Supplementation vs Placebo on Hospital Length of Stay in Patients with Severe COVID-19: A Multicenter, Double-blind, Randomized Controlled Trial.
doi: https://doi.org/10.1101/2020.11.16.20232397
Among hospitalized patients with severe COVID-19, vitamin D3 supplementation was safe and increased 25-hydroxyvitamin D levels, but did not reduce hospital length of stay or any other relevant outcomes vs placebo. This trial does not support the use of vitamin D3 supplementation as an adjuvant treatment of patients with COVID-19.
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